Know Your Organism

Time, Love, Memory: 

A Great Biologist and 

His Quest for the 

Origins of Behavior 

by Jonathan Weiner

“To know your organism, you must eat it.’ Not just the flies: the pupae. And not just to horrify people, but to know.”
― Jonathan Weiner, Time, Love , Memory: A Great Biologist and His Quest for the Origins of Behavior

This book is a highly regarded examination of the state-of-the-art in genetics and its discoveries regarding the biological foundations of behavior. It won the 1999 American National Book Critics Circle Award for General Nonfiction, highlighting the life and contributions of pioneering scientist Seymour Benzer and his groundbreaking studies of fruit flies (*Drosophila*).

It serves as an engaging biography of Seymour Benzer, a gifted and somewhat eccentric scientist who invented the use of fruit flies to investigate behavior's genetic foundation. Weiner details eloquently Benzer's path from physics to phage genetics and finally to the study of *Drosophila*, demonstrating his distinct method of scientific investigation. The book focuses on the "Fly Rooms" at Caltech, where thousands of mutant fruit flies were carefully examined to learn how genes affect intricate behaviors like learning and recall (memory), courtship rituals (love), and circadian rhythms (time). Tiny creatures, with their relatively simple genetic makeup, became invaluable models for understanding fundamental biological processes that have counterparts in humans.

Beyond Benzer's individual story, "Time, Love, Memory" provides a broader historical context for the field of genetics, tracing its evolution from Gregor Mendel's pea plants to the revolutionary discoveries of DNA by Watson and Crick and the subsequent explosion of molecular biology. Weiner adeptly connects Benzer's work to these larger scientific narratives.

Weiner excels at humanizing the scientific process, offering "you-are-there" descriptions of lab life and portraying the personalities of the scientists involved. He reveals the humor, quirks, frustrations, and triumphs that are inherent to scientific discovery, making complex ideas accessible and engaging for a wide audience. He also weaves in allusions to philosophy, literature, and popular culture, enriching the narrative.