
Empire of Pain: The Secret History of the Sackler Dynasty
Patrick Radden Keefe's 2021 book Empire of Pain: The Secret History of the Sackler Dynasty is a painstakingly detailed, compelling, and damning narrative nonfiction account of the Sackler family's ascent, Purdue Pharma, and their pivotal role in escalating the opioid crisis in the United States through the aggressive marketing of OxyContin.
The book is organized as a multigenerational family saga by Keefe. The story starts with the aspirational sons of Jewish immigrants in Brooklyn, Arthur Sackler and his brothers Mortimer and Raymond, who amassed wealth through creative (and frequently unethical) pharmaceutical marketing, advertising, and medical publishing. Arthur was involved with medications like Valium and helped develop direct-to-doctor advertising. The development and successful launch of OxyContin in the mid-1990s under the next generation (most notably Richard Sackler) are covered in the middle section. This includes the company's claims about its lower risk of addiction, high-pressure sales tactics, targeting of high-prescribing doctors, and attempts to minimize or deny issues as addiction and overdoses increased. The growing crisis (hundreds of thousands of opioid-related deaths), lawsuits, bankruptcy tactics, the family's extraction of billions while hiding personal wealth, their philanthropy (which bought prestige and name recognition on museums and universities), and their persistent refusal to take meaningful responsibility are all examined in the later sections.
All things considered, I thought the book was an insightful and captivating narrative history. A fascinating look at the development of one facet of the drug industry and a family story.
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